Chemistry & Biochemistry Seminar Series: Shuming Chen

As part of the Department of Chemistry & Biochemistry Seminar Series, Oberlin's own Assistant Professor of Chemistry and Biochemistry Shuming Chen will present on the topic "(Un)Leveling the Playing Field: Leveraging Destabilization in Transition-Metal-Mediated Reactions."

This seminar will be preceded by a light reception at 4:30 p.m. in the David Love Lounge.

Sponorsed by the Luke E. Steiner Lecture Fund.

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Abstract:

Transition-metal-mediated reactions have long served as a cornerstone of synthetic chemistry, enabling precise control over molecular transformations. However, achieving selectivity and efficiency in these processes often hinges on navigating complex energy landscapes and reaction intermediates. In this presentation, we explore the strategic use of destabilization as a tool of enhancing reactivity and selectivity in transition-metal catalysis. Through the application of density functional theory (DFT) calculations, we elucidate the electronic and steric factors that lead to selective destabilization of reactants or transition states, offering insights into how subtle perturbations can redirect reaction pathways. Our work underscores the synergy between theory and experiment in synthetic organic chemistry, paving the way for innovative strategies in catalyst development and reaction optimization.

Open to all members of the public